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Multimodality Therapy for Esophageal Cancer

Arlene A. Forastiere; Richard F. Heitmiller; Lawrence Kleinberg
Author and Funding Information

From the Departments of Oncology and Surgery, Johns Hopkins University School of Medicine, Baltimore


1997 by the American College of Chest Physicians


Chest. 1997;112(4_Supplement):195S-200S. doi:10.1378/chest.112.4_Supplement.195S
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Published online

Abstract

Over the past decade and a half, several strategies have been developed to improve the survival of patients with esophageal cancer. Two strategies employ either neoadjuvant chemotherapy or chemoradiotherapy followed by surgery to improve local-regional control and decrease the incidence of distant metastases. A third strategy uses nonsurgical therapy as definitive treatment for patients without metastatic disease. Single-institution pilot trials and randomized comparative trials have been conducted evaluating each approach. The rationale for these trials, results, and current recommendations are presented.


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