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Bilateral Sequential Lung Transplantation for Pulmonary Alveolar Microlithiasis

Jeffrey D. Edelman; Joseph Bavaria; Larry R. Kaiser; Leslie A. Litzky; Harold I. Palevsky; Robert M. Kotloff
Author and Funding Information

Affiliations: From the Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Surgery, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Pathology, University of Pennsylvania Medical Center, Philadelphia

Affiliations: From the Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Surgery, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Pathology, University of Pennsylvania Medical Center, Philadelphia

Affiliations: From the Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Surgery, University of Pennsylvania Medical Center, Philadelphia,  From the Department of Pathology, University of Pennsylvania Medical Center, Philadelphia


1997 by the American College of Chest Physicians


Chest. 1997;112(4):1140-1144. doi:10.1378/chest.112.4.1140
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Abstract

Pulmonary alveolar microlithiasis (PAM) is characterized by deposition of calcium phosphate within the alveolar airspaces. There is currently no effective medical therapy and affected individuals may progress to end-stage lung disease requiring transplantation. Two patients with PAM underwent bilateral sequential lung transplantation. This study reviews the clinical manifestations of PAM and discusses the particular difficulties that may be encountered in the use of lung transplantation as treatment for this uncommon disease. Also addressed is the question of recurrence in the allograft.


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