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A Possible Association of Chlamydia pneumoniae Infection and Acute Myocardial Infarction in Patients Younger Than 65 Years of Age

Francesco Blasi; Roberto Cosentini; Rita Raccanelli; Ferdinando M. Massari; Cristina Arosio; Paolo Tarsia; Luigi Allegra
Author and Funding Information

Affiliations: From the Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy,  From the Emergency Medicine Department, IRCCS Ospedale Maggiore, Milan, Italy,  From the Department of Cardiology, IRCCS Ospedale Maggiore, Milan, Italy

Affiliations: From the Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy,  From the Emergency Medicine Department, IRCCS Ospedale Maggiore, Milan, Italy,  From the Department of Cardiology, IRCCS Ospedale Maggiore, Milan, Italy

Affiliations: From the Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy,  From the Emergency Medicine Department, IRCCS Ospedale Maggiore, Milan, Italy,  From the Department of Cardiology, IRCCS Ospedale Maggiore, Milan, Italy


1997 by the American College of Chest Physicians


Chest. 1997;112(2):309-312. doi:10.1378/chest.112.2.309
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Abstract

Study objectives: We conducted a retrospective study on patients with acute myocardial infarction (AMI) and evaluated the incidence and prevalence of Chlamydia pneumoniae infection.

Methods: Sixty-one consecutive patients with AMI aged younger than 65 years were enrolled. Within 24 h of hospital admission, serum samples and pharyngeal swab specimens were obtained from all patients. In 49 of 61 patients, after a mean of 28 days from hospital admission, a second serum sample was drawn. A third serum sample was obtained in 23 of 61 patients. Serologic testing for Chlamydia pneumoniae was performed by a microimmunofluorescence test. We applied a nested-polymerase chain reaction for C pneumoniae DNA detection to pharyngeal swab specimens. Simultaneously, we performed a serologic study for C pneumoniae infection on 61 serum samples obtained from blood donors, matched for age, sex, and smoking habits.

Results: Serologic test results for C pneumoniae were consistent with acute reinfection in 12 patients, with chronic infection in 23 patients, and results were negative in 26 patients with AMI. In 3 of 12 patients with acute reinfection pattern and in 3 of 23 patients with chronic infection pattern, C pneumoniae DNA was detected on pharyngeal swab specimens. A significantly higher prevalence of IgG titers was observed in patients with AMI (35/61) compared to blood donors (18/61) (p=0.003).

Conclusion: Our data confirm the possible role of C pneumoniae infection in coronary heart disease and suggest that reinfection may trigger the onset of AMI.


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