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Pneumothorax as a First Manifestation of Sarcoidosis

Marios E. Froudarakis; Demosthenes Bouros; Argyro Voloudaki; Spyros Papiris; Yiannis Kottakis; Stavros H. Constantopoulos; Nikolaos M. Siafakas
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Affiliations: From the Department of Thoracic Medicine, Medical School, University of Crete, Greece,  From the Department of Radiology, Medical School, University of Crete, Greece,  From the Department of Thoracic Medicine, Medical School, University of loannina, Greece

Affiliations: From the Department of Thoracic Medicine, Medical School, University of Crete, Greece,  From the Department of Radiology, Medical School, University of Crete, Greece,  From the Department of Thoracic Medicine, Medical School, University of loannina, Greece

Affiliations: From the Department of Thoracic Medicine, Medical School, University of Crete, Greece,  From the Department of Radiology, Medical School, University of Crete, Greece,  From the Department of Thoracic Medicine, Medical School, University of loannina, Greece


1997 by the American College of Chest Physicians


Chest. 1997;112(1):278-280. doi:10.1378/chest.112.1.278
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Abstract

Pneumothorax is a rare manifestation of sarcoidosis, occurring usually late in the course of the disease. We report five cases of pneumothorax as a presenting manifestation of sarcoidosis. In two patients, thoracotomy showed extensive pleural infiltration by noncaseating granulomas. High-resolution CT scans showed cavitated subpleural nodules and subpleural bullae in one case. These findings support that necrosis of subpleural granulomas or rupture of a subpleural bullae, or both, are the mechanisms of pneumothorax in sarcoidosis. Three patients with a lung function impairment were treated with oral corticosteroids. One nontreated patient died due to progression of the disease.


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