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The Effect of Regular Salbutamol on Lung Function and Bronchial Hyperresponsiveness in Normal Subjects and Nonasthmatic Atopic Subjects With Allergic Rhinitis

David Boothman-Burrell; David Jones; G. Peter Herbison; D. Robin Taylor
Author and Funding Information

From the Departments of Respiratory Medicine and Preventive and Social Medicine, University of Otago Medical School, Dunedin, New Zealand


1997 by the American College of Chest Physicians


Chest. 1997;112(1):12-18. doi:10.1378/chest.112.1.12
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Abstract

Background: The effects of regular inhaled β-agonist treatment on lung function remain a controversial issue. In an earlier study, the administration of regular inhaled salbutamol resulted in negative changes in FEV1 not only in asthmatics, but also in nonasthmatic atopic subjects.

Objective: The aim of this study was to confirm these findings and also to examine whether regular inhaled salbutamol would increase bronchial hyperresponsiveness in atopic or normal individuals.

Design: The study was a randomized, double-blind, placebo-controlled, crossover investigation.

Participants: There were two groups: 10 normal healthy subjects (group A) and nine nonasthmatic atopic subjects (group B).

Interventions: Subjects received inhaled salbutamol or identical placebo for periods of 6 weeks, the dose being increased in stepwise fashion at 2-week intervals.

Measurements: Changes in lung function were assessed by measuring spirometric values, airways conductance, and changes in complete and partial expiratory flow volume curves. Changes in these parameters following a methacholine challenge were used to assess bronchial hyperresponsiveness.

Results: No statistically significant differences in lung function or bronchial hyperresponsiveness were noted to occur as the result of treatment in either group.

Conclusion: Our results do not support the view that regular inhaled salbutamol in normal or atopic subjects without asthma causes adverse changes in the airways.


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