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A Paradoxical Effect of Bronchodilators

Eric Maury; Vincent Ioos; Béatrice Lepecq; Bertrand Guidet; Georges Offenstadt
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From the Intensive Care Unit, Hôpital Saint Antoine, Paris, France


1997 by the American College of Chest Physicians


Chest. 1997;111(6):1766-1767. doi:10.1378/chest.111.6.1766
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Abstract

Lactic acidosis previously has been reported during treatment of asthma with beta-2 agonists. However, this metabolic disturbance never had any clinical consequence. We report a case of a patient with asthma in whom beta-2 agonist administration increased dyspnea by metabolic acidosis due to a sharp increase in lactate levels (hyperlactatemia) and led to inappropriate intensification of bronchodilator therapy.


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