Articles |

Gamma-Delta T Cells in BAL Fluid of Chronic Lower Respiratory Tract Infection FREE TO VIEW

Takeshi Fujii; Jun-ichi Kadota; Hiroshi Mukae; Kaoru Kawakami; Keiko Iida; Shigeru Kohno
Author and Funding Information

From the Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

1997 by the American College of Chest Physicians

Chest. 1997;111(6):1697-1701. doi:10.1378/chest.111.6.1697
Text Size: A A A
Published online


Gamma-delta (γ/δ) T cells are thought to represent the first line of defense against various pathogenic microorganisms. The aim of the present study was to investigate whether γ/δ T cells were increased in BAL fluid (BALF) of patients with diffuse panbronchiolitis (DPB), a model of chronic lower respiratory tract infection. The study population consisted of four groups, including patients with DPB, sarcoidosis, idiopathic pulmonary fibrosis, and normal subjects. Two-color direct immunofluorescence and flow cytometry were used for analysis of peripheral blood or BALF from these patients. The percentage of peripheral blood or BALF γ/δ T cells relative to the total number of lymphocytes was similar in the four groups. Although the absolute number of γ/δ T cells in BALF was significantly higher in DPB patients compared with the other three groups, the total lymphocyte number in BALF in DPB patients was increased and the number of BALF γ/δ T cells correlated with the total lymphocyte number in BALF. Furthermore, the percentage and number of BALF γ/δ T cells were not related to a certain group of pathogenic organisms or the number of colony-forming units. Our results suggest that γ/δ T cells are unlikely to play a part in chronic lower respiratory tract infection.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543