0
Articles |

Effect of Erionite on the Pleural Mesothelium of the Fischer 344 Rat

Armando E. Fraire; S. Donald Greenberg; Harlan J. Spjut; Ronald F. Dodson; Glenn Williams; Ella Lach-Pasko; Victor L. Roggli
Author and Funding Information

Affiliations: From the University of Massachusetts Medical Center, Worcester, Mass,  From the Baylor College of Medicine, Houston, Tex,  From The University of Texas Health Science Center at Tyler, Texas,  From the Duke University Medical Center, Durham, NC.

Affiliations: From the University of Massachusetts Medical Center, Worcester, Mass,  From the Baylor College of Medicine, Houston, Tex,  From The University of Texas Health Science Center at Tyler, Texas,  From the Duke University Medical Center, Durham, NC.

Affiliations: From the University of Massachusetts Medical Center, Worcester, Mass,  From the Baylor College of Medicine, Houston, Tex,  From The University of Texas Health Science Center at Tyler, Texas,  From the Duke University Medical Center, Durham, NC.

Affiliations: From the University of Massachusetts Medical Center, Worcester, Mass,  From the Baylor College of Medicine, Houston, Tex,  From The University of Texas Health Science Center at Tyler, Texas,  From the Duke University Medical Center, Durham, NC.


1997 by the American College of Chest Physicians


Chest. 1997;111(5):1375-1380. doi:10.1378/chest.111.5.1375
Text Size: A A A
Published online

Abstract

Objective: This study sought to assess the fibrogenic and carcinogenic potential of erionite (a fibrous zeolite) on the pleural mesothelium of the Fischer 344 rat (n=24).

Design: The study was designed to examine rat pleural mesothelial changes by three independent observers at timed intervals, ranging from 1 to 480 days postinoculation using erionite from the Pine Valley, Nevada (USA) area. The mean length and width of the erionite fibers were 2.29 and 0.48 µm, respectively. Only microscopic observations made by majority (2/3) or unanimity (3/3) were accepted for final diagnosis.

Results: Pleural and lung tissue were available for examination in 21 of the 24 rats. Fibrosis, chronic inflammation, and foreign body reaction occurred in 6 of 21 rats. Mesothelial hyperplasia and dysplasia occurred in 9 and 3 of the 21 rats, respectively. A single mesothelioma was identified at 434 days in a rat that had gross nodular pleural lesions.

Conclusions: The findings reported herein confirm the strong fibrogenic potential of erionite but are at variance with previous studies reporting much higher yields of mesothelioma. The reasons for the low yield of mesothelioma in this study are not known, but may be related to the study design, the strict criteria used for histopathologic diagnosis, and/or possible differences in erionite physicochemical properties, associated with its geographic distribution, most previous animal studies having used erionite from the Rome, Oregon (USA) area.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Topics

pleura

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543