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Pulmonary Alveolar Proteinosis : High-Resolution CT, Chest Radiographic, and Functional Correlations

Ki-Nam Lee; David L. Levin; W. Richard Webb; DeRong Chen; Maria L. Storto; Jeffrey A. Golden
Author and Funding Information

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco

Affiliations: From the Department of Radiology, University of California, San Francisco; the Department of Radiology, College of Medicine, Dong-A University, Pusan, Korea,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beth Israel Hospital, Boston,  From the Department of Radiology, University of California, San Francisco,  From the Department of Radiology, University of California, San Francisco; the Department of Radiology, Beijing (China) Hospital,  From the Department of Radiology, University of California, San Francisco; the Ist. di Scienze Radiologiche, Osp. "SS. Annunziata", Chieti, Italy,  From the Department of Internal Medicine, University of California, San Francisco


1997 by the American College of Chest Physicians


Chest. 1997;111(4):989-995. doi:10.1378/chest.111.4.989
Text Size: A A A
Published online

Abstract

Study objective: To determine whether a correlation exists between pulmonary function and both frontal chest radiographs and high-resolution chest CT findings in patients with pulmonary alveolar proteinosis (PAP).

Design: Retrospective review of radiographic and clinical data.

Setting: Tertiary referral hospital.

Patients: Seven patients with PAP were studied on 25 occasions using high-resolution chest CT (n=21), frontal chest radiographs (n=19), and pulmonary function tests (PFTs) (n=25).

Measurements and results: Visual estimates of the extent, degree, and overall severity of parenchymal abnormalities were determined for plain radiographs and high-resolution chest CT, and were correlated with PFTs. With high-resolution CT, the extent and severity of ground-glass opacity correlated significantly with the presence of a restrictive ventilatory defect, reduced diffusing capacity, and hypoxemia. Chest radiographic findings also correlated significantly with restrictive ventilatory defect, diffusing capacity, and hypoxemia.

Conclusion: In patients with PAP, although high-resolution CT correlates more closely with pulmonary function, plain radiographs should be sufficient for follow-up.


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