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Ciliary Beat Frequency in Human Bronchi and Bronchioles

Claude Clary-Meinesz; Jérôme Mouroux; Philippe Huitorel; Jacky Cosson; Damien Schoevaert; Bruno Blaive
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Affiliations: From the Service de Pneumologie, Hôpital Pasteur, Nice, France,  From the Service de Chirurgie Thoracique, Hôpital Pasteur, Nice, France,  From the U.R.A. 671 du C.N.R.S., Observatoire Océanologique, Ville-franche-sur-Mer, France,  From the Unité de Microscopie Quantitative, Laboratoire d'Anatomie Pathologique, Le Kremlin-Bicêtre, France

Affiliations: From the Service de Pneumologie, Hôpital Pasteur, Nice, France,  From the Service de Chirurgie Thoracique, Hôpital Pasteur, Nice, France,  From the U.R.A. 671 du C.N.R.S., Observatoire Océanologique, Ville-franche-sur-Mer, France,  From the Unité de Microscopie Quantitative, Laboratoire d'Anatomie Pathologique, Le Kremlin-Bicêtre, France

Affiliations: From the Service de Pneumologie, Hôpital Pasteur, Nice, France,  From the Service de Chirurgie Thoracique, Hôpital Pasteur, Nice, France,  From the U.R.A. 671 du C.N.R.S., Observatoire Océanologique, Ville-franche-sur-Mer, France,  From the Unité de Microscopie Quantitative, Laboratoire d'Anatomie Pathologique, Le Kremlin-Bicêtre, France

Affiliations: From the Service de Pneumologie, Hôpital Pasteur, Nice, France,  From the Service de Chirurgie Thoracique, Hôpital Pasteur, Nice, France,  From the U.R.A. 671 du C.N.R.S., Observatoire Océanologique, Ville-franche-sur-Mer, France,  From the Unité de Microscopie Quantitative, Laboratoire d'Anatomie Pathologique, Le Kremlin-Bicêtre, France


1997 by the American College of Chest Physicians


Chest. 1997;111(3):692-697. doi:10.1378/chest.111.3.692
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Abstract

Study objective: This study aimed to determine the differences between ciliary beat frequencies of respiratory ciliated cells from peripheral bronchioles and from proximal bronchi in humans.

Design: Measurements were made from resected lungs. Ciliated cells were harvested by brushing the mucosa of each site immediately after surgery. Brushings with a cytology brush were performed on normal areas of the resected cartilaginous bronchus for proximal samplings and through a peripheral bronchiole close to the visceral pleura for peripheral samplings. For each site, at least 12 different measurements were made at 22°C using an image analysis system.

Results: A highly significant difference between proximal bronchi (mean, 7.1 Hz; SD, 1.29) and peripheral bronchioles (mean, 4.6 Hz; SD, 1.39) (p<0.0001) was found.

Conclusion: Thus, cilia from peripheral bronchioles beat at a 35% lower beat frequency than cilia from proximal bronchi.


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