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Cytokine Gene Expression Profile of Circulating CD4+ T Cells in Active Pulmonary Tuberculosis FREE TO VIEW

Christopher K. W. Lai; Sheng Ho; Christopher H. S. Chan; Joseph Chan; Dominic Choy; Roland Leung; Kar-neng Lai
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From the Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

1997 by the American College of Chest Physicians

Chest. 1997;111(3):606-611. doi:10.1378/chest.111.3.606
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T lymphocytes, particularly CD4+ cells, are thought to play an important role in the immune defense against Mycobacterium tuberculosis through the release of their wide array of cytokines. In vitro studies suggest that Mycobacterium-specific T-cell clones are of the TH1 subtype. Using the technique of reverse transcription-polymerase chain reaction, we have investigated the capacity for cytokine gene expression profile in ex vivo circulating CD4+ T cells from 20 patients with active pulmonary tuberculosis compared with that of 30 normal healthy tuberculin-positive volunteers. Venous blood samples were collected from the former prior to the initiation of chemotherapy. A significant increase in interleukin (IL-2) expression (p< 0.001) and a significant decrease in IL-5 expression (p<0.0001) were observed in patients with tuberculosis but no differences were seen in the expression of IL-4 and interferon gamma between the two study groups. Our data support a TH1-like immune response in active tuberculosis.




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