Articles |

Effects of Left Ventricular Peak Filling Rate on Exercise Capacity 3 to 6 Weeks After Acute Myocardial Infarction FREE TO VIEW

Fumio Yuasa; Tsutomu Sumimoto; Toshihiko Hattori; Toshimitsu Jikuhara; Makoto Hikosaka; Tetsuro Sugiura; Toshiji Iwasaka
Author and Funding Information

From The Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan

1997 by the American College of Chest Physicians

Chest. 1997;111(3):590-594. doi:10.1378/chest.111.3.590
Text Size: A A A
Published online


Study objectives: To investigate the importance of early left ventricular (LV) diastolic filling on maintenance of exercise performance, we examined peak filling rate and its relation to exercise capacity during upright bicycle exercise in patients with recent myocardial infarction.

Design: Retrospective analysis of data of cardiopulmonary exercise testing characteristics in patients with recent myocardial infarction.

Setting: Coronary care unit in a university hospital.

Patients: Fifty-one patients 3 to 6 weeks after acute myocardial infarction.

Interventions: Upright bicycle exercise using a symptom-limited graded exercise protocol.

Measurements and results: Peak filling rate increased significantly from 1.55±0.52 at rest to 3.43±1.1 end-diastolic volume per second at peak exercise. Despite no significant relation between peak filling rate at rest and peak oxygen consumption, peak filling rate at peak exercise correlated significantly with peak oxygen consumption (r=0.50; p<0.002), stroke volume (r=0.51; p<0.002), and cardiac output (r=0.56; p<0.002) at peak exercise. Although both end-systolic and end-diastolic volumes increased from rest to peak exercise, the increases in end-systolic volume correlated inversely with the changes in peak filling rate during exercise (r=−0.45; p<0.02), but the increases in end-diastolic volume did not.

Conclusions: During maximal upright bicycle exercise, exercise capacity and exercise hemodynamic responses were mainly dependent on early LV diastolic filling, and preserved LV systolic contraction, resulting in a cardiac suction effect following early diastole, seemed to have an important role in the enhancement of early LV diastolic filling in patients with recent myocardial infarction.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543