0
Articles |

One Airway, One Disease FREE TO VIEW

Jay Grossman
Author and Funding Information

From the University of Arizona College of Medicine, Tucson


1997 by the American College of Chest Physicians


Chest. 1997;111(2_Supplement):11S-16S. doi:10.1378/chest.111.2_Supplement.11S
Text Size: A A A
Published online

Abstract

The prevalence of asthma and allergic rhinitis is increasing in the general population, and a high proportion of new patients have coexisting upper and lower airway disease. Estimates show that 60 to 78% of patients who have asthma have coexisting allergic rhinitis. During the past decade, our understanding of asthma and allergic rhinitis has evolved. The historic perspective of these allergen-induced disorders as distinct and separate entities is being displaced by current thinking that they are described better as a continuum of inflammation involving one common airway. Therefore, traditional therapies originally indicated for allergic rhinitis and asthma are being reassessed to explore their potential utility in both upper and lower airway diseases. Recently, there has been a renewed interest in the role that histamines play in lower airway disease, and interest is increasing in the theory that leukotrienes, which are far more potent inflammatory mediators than histamines, play a role in upper airway disease. Given the pivotal role that leukotrienes play as potent inflammatory mediators in the pathophysiologic state of inflammation of both airways, leukotriene receptor antagonists recently have emerged as important therapeutic advances that have potential clinical utility in both asthma and allergic rhinitis.


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
Mucopolysaccharidosis type II, Hunter's syndrome. Pediatr Endocrinol Rev 2014;12 Suppl 1():107-13.
A method to describe the pharyngeal airway. Laryngoscope Published online Oct 24, 2014.;
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543