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A Rapid Desktop Theophylline Assay : Evaluation of Use in Clinical Management

John L. Kiely; Geraldine Lawless; Walter T. McNicholas; Sean Cunningham
Author and Funding Information

Affiliations: From the Department of Respiratory Medicine, St. Vincent's Hospital, Elm Park, Dublin, Ireland,  From the Department of Biochemistry, St. Vincent's Hospital, Elm Park, Dublin, Ireland

Affiliations: From the Department of Respiratory Medicine, St. Vincent's Hospital, Elm Park, Dublin, Ireland,  From the Department of Biochemistry, St. Vincent's Hospital, Elm Park, Dublin, Ireland


1997 by the American College of Chest Physicians


Chest. 1997;111(2):324-326. doi:10.1378/chest.111.2.324
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Abstract

Study objectives: To assess the practicality and precision of a simple desktop theophylline assay (Biotrack 516TM) in comparison to a standard laboratory assay system (Abbott TDxTM).

Design: A prospective blinded paired sample study.

Setting: The respiratory ward and outpatient clinics, the pulmonary function and biochemistry laboratories of a university teaching hospital.

Patients: Sixty patients with asthma or COPD attending the respiratory service.

Measurements and results: Paired specimens for theophylline assay were collected simultaneously for analysis. There was a highly significant (p<0.001) correlation between the two assay systems for both the total range studied (1.2-39.1 µg/mL; r=0.98), and the clinically important range of 5-15 µg/mL (r=0.95). The limits of agreement for the data by the Bland and Altman method indicated a ±2 µg/mL limit for the 5-15 µg/mL range and a ±2.7 µg/mL limit for the total range studied.

Conclusions: The Biotrack 516 is an easy-to-use system, which provides rapid and reasonably precise measurements of serum theophylline levels. The device should be of particular value in smaller centers without an on-site laboratory assay system.


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