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Nonspecific Airway Hyperresponsiveness in HIV Disease

Jeanne Marie Wallace; Gregory S. Stone; Paul A. Kvale; Ben L. Browdy; Donald P. Tashkin; Philip C. Hopewell; Jeffrey Glassroth; Mark J. Rosen; Lee B. Reichman; Pulmonary Complications of HIV Infection Study Group
Author and Funding Information

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ


Affiliations: From the Department of Medicine, Olive View-UCLA Medical Center, Sylmar, Calif; the University of California, Los Angeles,  From the Department of Medicine, Henry Ford Hospital, Detroit,  From the Department of Medicine, University of California, Los Angeles,  From the Department of Medicine, the University of California, San Francisco,  From the Department of Medicine, Northwestern University, Chicago,  From the Department of Medicine, Beth Israel Medical Center, New York,  From the Department of Medicine, the University of Medicine and Dentistry, Newark, NJ

1997 by the American College of Chest Physicians


Chest. 1997;111(1):121-127. doi:10.1378/chest.111.1.121
Text Size: A A A
Published online

Abstract

Objectives: HIV disease is frequently complicated by episodic acute bronchitis, suggesting the presence of chronic bronchial inflammation. To further examine this concept, we investigated the possible association of nonspecific airway hyperresponsiveness (AHR) and HIV disease.

Design: Methacholine inhalation challenge studies were performed on 66 HIV-seropositive and 8 HIV-seronegative members of the Pulmonary Complications of HIV Infection Study Cohort. AHR was defined as 20% or more decline in FEV1 from the postdiluent value after inhalation of 125 or less cumulative breath units. The prevalence of AHR in HIV-seropositive cohort members was compared with that in matched control subjects who had undergone methacholine challenge testing for two unrelated studies. Demographic, behavioral, and clinical features in HIV cohort members with and without AHR were contrasted. The relationship between AHR and the occurrence of episodic airway disease or symptoms suggestive of airway disease was examined.

Results: AHR was not more prevalent in HIV-seropositive cohort members than control subjects (19.3% vs 12.9%; p>0.1). Within the cohort, AHR was detected more frequently in members with than without a history of asthma (60% vs 16%; p<0.05). A greater proportion with than without AHR had 1 or more episode of pneumonia within 2 years (46% vs 9%; p<0.01), 1 or more asthma episode during the study period (39% vs 1.9%; p<0.001), or wheeze noted during clinic visits (62% vs 17%; p<0.01). The proportion that experienced acute bronchitis did not differ in the two groups.

Conclusions: This study suggests that HIV-infected persons do not have increased prevalence of nonspecific AHR. In HIV disease, AHR is associated asthma, but not episodic acute bronchitis. Thus, the possibility that airway injury without demonstrable AHR might complicate HIV disease remains.


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