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Morphometric Evaluation of Argyrophilic Nucleolar Organizer Region Is Useful in Predicting Long-term Survival in Squamous Cell Carcinoma of the Lung

Leila Antonangelo; Fabiola Del Carlo Bernardi; Vera Luiza Capelozzi; Tereza Yae Takagaki; Riad Naim Younes; Neide Yagi; Paulo Hilário Nascimento Saldiva
Author and Funding Information

Affiliations: From the Laboratory of Experimental Air Pollution, Department of Pathology, University of São Paulo, Brazil,  From Discipline of Pneumology, Faculty of Medicine, University of São Paulo, Brazil,  From the Department of Thoracic Surgery, Hospital A.C. Camargo, São Paulo, Brazil

Affiliations: From the Laboratory of Experimental Air Pollution, Department of Pathology, University of São Paulo, Brazil,  From Discipline of Pneumology, Faculty of Medicine, University of São Paulo, Brazil,  From the Department of Thoracic Surgery, Hospital A.C. Camargo, São Paulo, Brazil

Affiliations: From the Laboratory of Experimental Air Pollution, Department of Pathology, University of São Paulo, Brazil,  From Discipline of Pneumology, Faculty of Medicine, University of São Paulo, Brazil,  From the Department of Thoracic Surgery, Hospital A.C. Camargo, São Paulo, Brazil


1997 by the American College of Chest Physicians


Chest. 1997;111(1):110-114. doi:10.1378/chest.111.1.110
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Abstract

Nucleolar organizer regions identified by means of an argyrophilic technique (AgNOR) were quantified by digital image analysis in 81 patients with squamous cell carcinoma of the lung. Survival rate was modeled as function of AgNOR expression by Cox regression models controlled for staging, histologic grade, age, and sex. Our results indicate that AgNOR expression has a significant prognostic role. Tumors at lower stages have a lower expression of AgNOR than those with more advanced disease. Tumors with high histopathologic grade have a higher expression of AgNOR. Patients with low AgNOR expression presented a higher survival rate than those with higher amounts of AgNOR. The foregoing results strongly encourage the development of prospective trials to assess the real role of AgNOR in determining prognosis in squamous cell carcinoma of the lung.


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