0
Articles |

Forced Oscillation Technique vs Spirometry to Assess Bronchodilatation in Patients With Asthma and COPD FREE TO VIEW

Françoise Zerah; Anne-Marie Lorino; Hubert Lorino; Alain Harf; Isabelle Macquin-Mavier
Author and Funding Information

From the Service de Physiologie-Explorations Fonctionnelles, Service de Pharmacologie Clinique et INSERM U 296, Hôpital Henri Mondor, Créteil, France


1995 BY THE AMERICAN COLLEGE OF CHEST PHYSICIANS


Chest. 1995;108(1):41-47. doi:10.1378/chest.108.1.41
Text Size: A A A
Published online

Abstract

The forced oscillation technique (FOT) is a noninvasive test used to characterize the mechanical impedance of the respiratory system. The aim of the study was to compare the changes in respiratory conductance (Grs) measured with FOT to those in FEV1 in 22 patients with asthma and 20 patients with chronic obstructive pulmonary diseases (COPD) after salbutamol inhalation. FEV1 and Grs indexes, computed as the ratio of the difference between postbronchodilator and prebronchodilator values over the predicted value, were used to express reversibility of airway obstruction. After inhalation of salbutamol in cumulative doses up to 1,200 µg in ten patients of each group, FEV1 and Grs indexes showed parallel changes, and most of the increase was observed after the first dose of 200 µg of salbutamol for the two indexes. In all the 42 patients, we found a linear relationship between the two indexes after inhalation of 200 µg of salbutamol (r=0.7, p<0.0001). We evaluated FEV1 and Grs indexes in terms of sensitivity and specificity for identifying asthmatics among patients with COPD: using a 10% change as the cut-off value, these indexes proved of similar value (sensitivity, 0.91 and 0.95; specificity, 0.95 and 0.85, respectively). We conclude that the use of FOT can be considered as an alternative to forced expiration for detecting bronchodilatation in asthmatics and patients with COPD.


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
A Randomized Controlled Trial on Office Spirometry in Asthma and COPD in Standard General Practice *: Data From Spirometry in Asthma and COPD: a Comparative Evaluation Italian Study
The Importance of Spirometry in COPD and Asthma*: Effect on Approach to Management
The Proportional Venn Diagram of Obstructive Lung Disease*: Two Approximations From the United States and the United Kingdom
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543