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Danger of vasodilator therapy for pulmonary hypertension in patent foramen ovale.

J F Laine; M Slama; P Petitpretz; P Girard; G Motté
Chest. 1986;89(6):894-895. doi:10.1378/chest.89.6.894
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Abstract

A 23-year-old woman with systemic lupus erythematosus was found to have severe pulmonary hypertension with secondary patency of the foramen ovale. Infusion of hydralazine increased the basal right-to-left shunt and resulted in a dramatic fall in arterial oxygen pressure, with subsequent irreversible cardiovascular collapse. Vasodilator therapy appears to be hazardous in patients with severe pulmonary hypertension and patent foramen ovale.


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