PURPOSE: It is well-known that smoking leads to a reduction in exhaled nitric oxide (FeNO) levels. There is, however, limited knowledge in relation to the smoking-induced changes in the production or exchange of NO in different compartments of the airways. The aim of the present study is to provide evidence of the immediate effects of smoking a single cigarette on the partitioning of NO , in young adults.
METHODS: **Sixteen (16) young healthy volunteers (eight male and eight female) with a mean age of 23 ± 0,47 years with a smoking history of less than 8 packyears, were studied. FeNO (Ecomedics CLD 88sp) measurements were performed before and immediately after smoking a single cigarette of their usual brand, at 50 mL*s-1 ,followed by three additional flow rates (30, 100 and 300 mL*s-1) .FeNO,alveolar NO (CaNO) and three NO exchange parameters(a,b,c)were calculated using the algorithm by M. Högman and P. Meriläinen, for the alveolar NO determination. Parameters measured were(a)JawNO which represents the flux of NO in the airway compartment and contains (b)CawNO ,the airway tissue concentration of NO and finally (c) DawNO , the total airway compartment diffusing capacity. Meausurements were analyzed, using the non parametric sign test for paired values. **Results expressed as mean ± Standard Error.
RESULTS: After smoking of a cigarette, FeNO (ppb)was decreased by 15,6% from 10,64±1,2 to 8,98±1,0 p<0,001). CaNO was increased by 42,6% from 1,22 ±0,4 to 1,74 ± 0,6 (p=0,017) while JawNO decreased by 15,8% from 587 ± 76,6 to 494 ± 60,7 (p=0,047). CawNO was increased by 26,0 % from 33,8± 4,6 to 42,6± 11,3 (p=0,21) and finally DawNO was non significantly increased by 2,5 %(p=0,49)
CONCLUSIONS: Smoking of a single cigarette decreases FeNO and increases CaNO , leading to a limited flux of NO in the airway compartment in young adults.
CLINICAL IMPLICATIONS: Even smoking of a single cigarette causes immediate effects on the partitioning of nitric oxide in young adults.
DISCLOSURE: The following authors have nothing to disclose: Marios Kougias, Constantine Vardavas, Nektarios Anagnostopoulos, Andrianni Loukopoulou, Vassiliki Evangelopoulou, Miltos Vasilleiou, Panagiotis Behrakis
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