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Poster Presentations: Tuesday, October 25, 2011 |

Correlation of Coronary Artery Calcification With Severity of Myocardial Ischemia in Left Anterior Descending, Left Circumflex, and Right Coronary Artery Territories FREE TO VIEW

Hoang Lai, MD; Wilbert Aronow, MD; Albert Deluca, MD; Chul Ahn, PhD; Dvorah Holtzman, MD; Svetlana Matayev, MD; Robert Belkin, MD
Chest. 2011;140(4_MeetingAbstracts):247A. doi:10.1378/chest.1119808
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Abstract

PURPOSE: We correlated the level of coronary artery calcification (CAC) with the severity of myocardial ischemia diagnosed by myocardial perfusion imaging (MPI) in the left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territories.

METHODS: The study included 113 men and 93 women, mean age 66 ± 11 years, without cardiac stents or coronary artery bypass surgery who had coronary computed coronary angiography and MPI within 3 months of each test. CAC levels were measured from the LAD, LCX, and RCA. Ischemia from each vessel territory diagnosed from MPI was diagnosed as none, mild, moderate, or severe. Analysis of variance (ANOVA) test was used to examine for significant differences in LAD, LCX, and RCA calcium scores between moderate or severe ischemia versus no or mild ischemia. Stepwise linear regression analysis was conducted to identify significant risk factors for LAD, LCX, and RCA CAC scores.

RESULTS: Moderate or severe LAD ischemia was present in 9 of 206 patients (4%). CAC score was insignificantly higher in patients with moderate or severe LAD ischemia (p = 0.091). Moderate or severe LCX ischemia was present in 10 of 206 patients (5%). CAC score was significantly higher in patients with moderate or severe LCX ischemia (p = 0.01). Moderate or severe RCA ischemia was present in 14 of 206 patients (7%). CAC score was significantly higher in patients with moderate or severe RCA ischemia (p = 0.003). After controlling the effect of age and gender, patients with moderate or severe LCX or RCA ischemia had significantly higher CAC scores than those with mild or no ischemia ( p = 0.0043 and p = 0.0347, respectively).

CONCLUSIONS: Patients with moderate or severe LCX or RCA ischemia have significantly higher CAC scores than those with no or mild ischemia. Patients with moderate or severe LAD ischemia have insignificantly higher CAC scores than those with no or mild ischemia.

CLINICAL IMPLICATIONS: Patients with moderate or severe LCX or RCA ischemia have significantly higher CAC scores than those with no or mild ischemia. Patients with moderate or severe LAD ischemia have insignificantly higher CAC scores than those with no or mild ischemia.

DISCLOSURE: The following authors have nothing to disclose: Hoang Lai, Wilbert Aronow, Albert Deluca, Chul Ahn, Dvorah Holtzman, Svetlana Matayev, Robert Belkin

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