PURPOSE: Considerable number of COPD patients (pts) suffers from dyspnea and exercise limitation. These symptoms are not in close relation with FEV1 nor GOLD severity. In addition there is apparent individual susceptibility to dyspnea sensation.
METHODS: We measured dyspnea (MRC dyspnea scale) and prognostic indexes (ADO, classical BODE 2004, modified BODE 2009) of COPD pts and compared these parameters in male and female subgroups.
RESULTS: We used data from observational crossectional assessment of stable ex-smokers with mild (n 23), moderate (n 25), severe (n 25) and very severe (n 25) COPD. All 98 pts (79 males, 65.1 years, FEV1 55.5% SD22.7) were randomly recruited from all our out-patients (n 620). Severity of bronchial obstruction (FEV1%) was idenical in both subgroups. The mean values of MRC in males and females subgroups were 1.84 and 2.42 respectively. The values of MRC were higher for women in all stages of the disease (stage I- males 1.24 and females 2.50, II- 1.41 and 2.33, III - 1.86 and 2.33, IV - 2.89 and 3.29). Inter-gender difference was statistically significant (p=0.028 chi square test). Although we did not find any significant difference between the prognostic parameters (ADO, classical and modified BODE) in males and females, women achieved a higher score in all three indexes.
CONCLUSIONS: We confirmed gender difference in the perception of dyspnea among ex-smokers with COPD. We did not show significant gender difference in values of prognostic indexes.
CLINICAL IMPLICATIONS: Women are more susceptible to dyspnoea. This would likely lead to a modification of our therapeutic interventions in female subjects with COPD.
DISCLOSURE: The following authors have nothing to disclose: Vladimir Koblizek, Sarka Pracharova, Kamil Klenha
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