Poster Presentations: Tuesday, October 25, 2011 |

Ciliary Architecture Abnormalities in a Series of Pediatric Patients With Chronic Oto-Sino-Pulmonary Disease FREE TO VIEW

Edith Allen, MD; Barbara Stewart, MD
Chest. 2011;140(4_MeetingAbstracts):386A. doi:10.1378/chest.1119431
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PURPOSE: The purpose of our investigation is to find if there is an association between the percentage of ciliary microtubular architecture abnormalities in cases where pathologic evidence suggested secondary ciliary changes vs. those with possible primary ciliary abnormalities.

METHODS: Consecutive neuropathology reports of transmission electron microscopy examining ciliary architecture of nasal and/or carina specimens were obtained from the period of August 1st 2007 to December 31st 2010.

RESULTS: 226 reports were obtained (160 patients), 45 samples were excluded (40 due the specimen being inadequate for ultrastructural evaluation and five due to the lack of a quantitative report of the number of abnormal cilia). 181 reports were the final sample (138 patients). The median age of patients was 6.72 (range 5months-21 years). 80 out the 138 patients were male (57.9%). Based on the pathology report, the138 patients were divided into group A (normal 9+2 architecture and/or reactive architectural changes, n=64) vs. group B (samples with abnormal cilia architecture without pathologic evidence of reactive changes - based on the percentage of compound cilia and regional ciliary architectural abnormalities, n=74). There was no difference between the percentage of compound cilia in Group A and B (mean=6). In the other hand, the percentage of cilia with architectural abnormalities was 5% vs. 12.77% for group A and B respectively.

CONCLUSIONS: The percentage of architectural ciliary abnormalities was significantly higher in cases where no evidence of secondary ciliary changes occurred due to chronic infections.

CLINICAL IMPLICATIONS: Even though the common denominator in our population was the history of chronic oto-sino-pulmonary disease, which make ciliary microtubular architecture interpretation difficult to differentiate as primary vs. secondary, our study suggest that a higher percentage of 9+2 microtubular architectural abnormalities is expected in cases where primary ciliary abnormalities is a possibility.

DISCLOSURE: The following authors have nothing to disclose: Edith Allen, Barbara Stewart

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