PURPOSE: The association between Obstructive Sleep Apnea (OSA) and cardiovascular risk has been established by scientific evidence during the past years. Aim of this study was to assess mean platelet volume (MPV), a possible marker of cardiovascular risk in OSA patients, as well as to investigate the associations between MPV and anthropometric characteristics and parameters of breathing function during sleep.
METHODS: Included were 699 individuals, examined with physical examination and PSG, due to suspected sleep apnea. Sleepiness had been assessed by Epworth Sleepiness Scale (ESS). According to their AHI, patients were divided into 4 groups. Group A (n=156) with AHI<5/h; Group B (n=137) AHI: 5-14.9/h; Group C (n=100) AHI: 15-29.9/h and Group D (n=303) AHI ≥30/h. MPV was measured in two blood cell counters (Sysmex SF 3000 and Cell-Dyn 3700). Blood samples were anticoagulated with sodium citrate.
RESULTS: MPV was significantly higher in group D (mean value 11.7±1.2) than in groups A (9.9±1.2), B (9.9±1.6), and C (10.8±1.8) (p <0.001). MPV significantly correlated with AHI (p<0.001), average SpO2 (p<0.001), minimum SpO2 (p<0.001), t<90 (p<0.001), Arousal Index (p<0.001) and ESS (p=0.002). Regression analysis revealed no association between MPV, BMI (p=0.855) and age (p=0.774).
CONCLUSIONS: MPV values correlate well with indexes of OSA severity, indicating a higher cardiovascular risk, as OSA severity increases.
CLINICAL IMPLICATIONS: This study suggests that MPV could serve as a marker of OSA severity, explaining partially the association between OSA and increased cardiovascular risk.
DISCLOSURE: The following authors have nothing to disclose: Paschalis Steiropoulos, Evangelia Nena, Nikolaos Papanas, Stavros Anevlavis, Konstantinos Archontogeorgis, Pavlos Zarogoulidis, George Zacharis, Andreas Koulelidis, Argyrios Tzouvelekis, Ioannis Angomachalelis, Marios Froudarakis, Demosthenes Bouros
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