PURPOSE: Measurement of fractional exhaled nitric oxide (FENO) has become a clinical routine in the assessment of airway inflammation. Recently, a portable device for measuring FENO levels was developed. FENO values obtained using this analyser correlate well with those obtained using a chemiluminescence analyser . However, there has been no Asian data for repeatability of successive measurements until now. This study purpose is to determine the repeatability of successive FENO measurements with the portable device among healthy Korean volunteers.
METHODS: The FENO measurements were carried out in accordance with the current ATS/ERS recommendations using a portable device for measuring FENO levels in healthy Korean volunteers. Three successive FENO measurements were performed with an interval of 4-5 minutes, and then, they performed pulmonary function tests.
RESULTS: Forteen Korean healthy volunteers were enrolled in this study. The mean values of the 3 successive FENO measurements were 23.5±6.5 ppb, 23.6±7.7 ppb and 23.5±6.9 ppb. There was no significant statistical difference among 3 successive measurements.
CONCLUSIONS: The mean FENO values are relatively higher than previous western data. There was no significant statistical difference among 3 successive measurements.
CLINICAL IMPLICATIONS: The mean FENO values in healthy Korean volunteers are relatively higher than previous western data. There was no significant statistical difference among 3 successive FENO measurements. Repeated determinations of FENO may not necessary for screening in Koreans.
DISCLOSURE: The following authors have nothing to disclose: JaeHyung Lee, Byoung Hoon Lee, Sang-Hoon Lee
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