PURPOSE: To compare clinics differences in non smokers (NS) with Non small cell lung cancer (NSCLC) versus NSCLC in smokers (S)
METHODS: Retrospectively collected data on 485 patients undergoing lung resection for NSCLC between 1985 and 2009 in a single unit were analysed. NS were considered those who has had a lifetime exposure of less than 100 cigarettes
RESULTS: Reliable information was available in 446 patients, 57 (12,8%) were NS. NS were younger (60,6± 10,2 vs 63,7 ± 9, 4, p = 0,030) and more likely to be women (49,1 vs 23,1%, p = <0 ,0001) and being asymptomatic at the time of diagnosis (74,5 vs 57,1%, p = 0,012). There were not different in other clinics characteristic or complication rate, or operative mortality. The prevalence of a previous malignancy was higher in NS. During surgery, requirement of a pneumonectomy was not different, neither the proportion of a patients with a resection considered curative or with a pathological N2. The prevalence of Bronchioloalveolar carcinoma was higher in NS(17.3 vs 3.6, p = 0,001), but the adenocarcinoma was the most frequent histology in both groups.Overall survival was not different (p = 0,336). If only patients in Stage I was considered there were not differences in 5-year survival.
CONCLUSIONS: In our group of patients never smokers were younger, more frequently asymptomatic and with a higher prevalence of women and adenocarcinoma histology. There were no differences in the 5-year survival after surgical resection.
CLINICAL IMPLICATIONS: With the finding of somatic mutations of epidermal growth factor receptor, this group could have different therapeutics response.
DISCLOSURE: The following authors have nothing to disclose: Ileana Palma, Silvia Quadrelli, Sebastian Lamot, Lorena Delisio, Marcos Hernandez, Gustavo Lyons, Domingo Chimondeguy
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