PURPOSE: Vitamin D was initially thought only to function in calcium homeostasis. However, it has multiple roles in human health, including immune modulation. There are evidence based studies suggesting the role of active vitamin D metabolite, (1, 25-dihydroxyvitamin D), and the effects on both innate and acquired immunity. Sarcoid granuloma derived 1, 25-hydroxyvitamin D leads to hypercalcemia, but the association of 1, 25-dihydroxyvitamin D with the clinical phenotype of the disease is currently unknown. (*Elevated 1, 25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis. Kavathia D, Buckley J, Rao D, Rybicki B, Burke R. Respiratory Medicine .2010; 104, 564-570). Another form of D vitamin - 25(OH) D3 has low biological activity, but it is the major form of vitamin D that circulates in the blood stream. The purpose of this study was to determine the relationship (if any) between serum 25(OH) D3 vitamin levels, with the degree of sarcoidosis chronicity.
METHODS: 86 biopsy positive sarcoidosis patients were enrolled in this study: (64 female/ 22 male). 25(OH) D3 was evaluated in the Biochemical Department, Clinical Center Belgrade, Serbia , using electrochemiluminescent immunoassay (ECLIA). The reference values were as follows: deficiency < 10 ng/ml, insufficiency 10-30 ng/ml, desirable > 30 ng/ml 44/86 patients had acute disease, while 42/86 patients had chronic sarcoidosis.
RESULTS: In the analyzed group of sarcoidosis patients with acute disease 13/44 patients (29.5%) had insufficiently low 25(OH) D3 vitamin levels while in the group of patients with chronic disease 27/42 (64.2%) patients had insufficiently low 25(OH) D3 vitamin levels ( 25(OH) D3 serum level < 4 ng/ml).
CONCLUSIONS: Statistically significant correlation was found between the serum 25(OH) D3 vitamin levels and sarcoidosis chronicity. (Chi-square= 10.424; df=1; p=0.001) in our patients
CLINICAL IMPLICATIONS: not only 1, 25-dihydroxyvitamin D as an active metabolite can predicted the sarcoidosis chronicity; 25(OH) D3 vitamin levels - the major form of vitamin D that circulates in the blood stream seems to be possible predictor of sarcoidosis chronicity.
DISCLOSURE: The following authors have nothing to disclose: Violeta Vucinic, Zorica Sumarac, Mira Vukovic, Mihailo Stjepanovic, Maja Omcikus, Jelica Videnovic, Vesna Skodric-Trifunovic, Snezana Filipovic
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