PURPOSE: Evaluation of possible relationships between Sleep Apnea Syndrome (SAS) and biomarkers of oxidative stress.
METHODS: Two Romanian groups, consisting of 35 patients diagnosed with SAS and 17 healthy controls, were recruited. All subjects underwent cardiorespiratory poligraphy. Plasma levels of homocysteine (Hcy), gluthatione reductase (GSSG-Red), gluthatione peroxidase, copper/zinc (Cu/Zn)-Superoxide dismutase (SOD1), endothelin-1 (ET1), low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides, uric acid, glycemia and thrombocytes were assessed. Statistical analysis was performed using Spearman and Pearson correlations tests, two tailed t-test, Kruskal-Wallis test and one-way ANOVA test.
RESULTS: Positive correlations were found as follows: in the study group, between apnea-hypopnea index (AHI)-ET1 (r=-0.40; p=0.01); AHI-uric acid (r=0.37; p=0.02); AHI-thrombocytes (r=-0.33; p=0.05); glycemia-snoring (r=0.38; p=0.02), while in the control group, between Hcy-sleep duration (r=055; p=0.001); Hcy/BMI-HDL (r=0.44; p=0.001); GSSG-Red-uric acid (r=-0.48; p=0.04). With regard to the smoking status, the SOD1 values were statistically significant higher in smokers than non-smokers (p=0.01).
CONCLUSIONS: Plasma GSSG-Red, Hcy, SOD1 and ET1 levels may be used as possible markers to provide information related to oxidant/antioxidant status in SAS patients, making them more prone to developing proatherosclerotic disease.
CLINICAL IMPLICATIONS: In SAS the episodes of hypoxia/reoxygenation can generate reactive oxygen species and promote oxidative stress. A better understanding of the relationship between SAS, biomarkers of oxidative stress and the sophisticated antioxidant defense system may have important clinical implications.
DISCLOSURE: The following authors have nothing to disclose: Ligia Puiu, Andreea Didilescu, Stefan Dan Mihaicuta, Paraschiva Postolache, Ovidiu Fira-Mladinescu, Anca Petrovan, Ioan Alexandru Somesan, Alexandra Totan, Maria Greabu, Cristian Didilescu, Florin Mihaltan
We don't have any conflicts of interest.