PURPOSE: The aim of this study was to understand the clinical features of hospitalized patients with influenza A(H1N1) and investigate the predictive factors associated with long hospitalized patients.
METHODS: From January 1.2009 to December 31.2010, thirty-four patients with influenza A(H1N1) was hospitalized. They were positive for novel influenza A(H1N1) viral RNA by real time PCR in nasopharyngeal swap. We retrospectively analysed using medical record. Hospital day was divided according to short hospitalization (≤ 7days) and long hospitalization(≥8days). To evaluation of nutritional assement, we used total lymphocyte count (TLC= WBC count X lymphocyte ratio) and albumin.
RESULTS: Each 17 patients had short and long hospitalization. Mean age of them was 30 ± 14.3 and 57.2± 16.4 year old. Long hospitalization patients showed lower total lymphocyte count and albumin(920±533.8:1040.7±479.1, 3.7±0.57:4.1±0.28). They had longer from symptom to admission and medication(oseltamivir or zanamivir) than short hospitalization patients(4.4±2.6:2.4±0.9, 6.3±3.3:2.8±1.4 days). Also they had higher systolic blood pressure, CRP, AST, ALT, glucose, BUN and creatine. But they had lower PO2(63.8±13.2:94.2±26.0). Four patients of thirty-four patients expired. All expired patients were included long hospitalization part.
CONCLUSIONS: long hospitalization in pandemic influenza H1N1 virus infection may be associated with age, admission from symptom and medication. It had higher systolic blood pressure, CRP, AST, ALT, BUN, glucose than short hospitalization. But It had lower TLC, albumin, PO2 than short hospitalization. Treatments and admission at early stage probably reduce hospital day. Also good nutritional support may be associated with short hospital days.
CLINICAL IMPLICATIONS: This study was help to understand about clinical feature of hospitalized patients with influenza A(H1N1) and investigate the predictive factors associated with long hospitalized patients.
DISCLOSURE: The following authors have nothing to disclose: YuJin Kim, SunYoung Kyung, Jeong-Woong Park, SangPyo Lee, SungHwan Jeong
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