Poster Presentations: Wednesday, October 26, 2011 |

The Relationship Between Serum Ferritin Levels, Smoking, and Lung Function in Korean: Analysis of the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) FREE TO VIEW

Su Hwan Lee, MD; Eun Young Kim, MD; Sang Kook Lee, MD; Ji Young Hong, MD; Young Sam Kim, MD
Chest. 2011;140(4_MeetingAbstracts):568A. doi:10.1378/chest.1118951
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PURPOSE: Cigarette smoking particles usually have been accumulated for a long times, these particles alter iron homeostasis systemically. Especially cigarette smoking particles change iron homeostasis in the lung. In the previous studies, serum ferritin levels in cigarette smoker were elevated and increased with age. The purpose of this study is to investigate the relationship between cigarette smoking, lung function and serum ferritin concentrations in Korean people using nationwide survey data.

METHODS: During 2008, the second year of Korea National Health and Nutrition Examination Survey (KNHANES) IV, 500 survey areas were drawn from a census of population and housing by considering the proportion of each subgroup. Spirometry was performed and a trained interviewer administered a questionnaire on smoking status and other health information. Serum ferritin levels were measured by immune-radiometric assay using 1470 WIZARD gamma-Counter (PerkinElmer/Finland). All data were measured by standard manner and reviewed by central quality control center.

RESULTS: Serum ferritin levels were measured in 6,703 adults aged more than 18. Among them male were 2,832(42.3%) and female were 3,871(57.7%). Among whom responded smoking questions, 4,002(60.8%) were non-smokers and 2,576(39.2%) were ever-smokers. Current smokers were 1,497 and ex-smokers were 1,262. Serum ferritin levels were higher in smokers. Mean serum ferritin levels were 119.8ng/mL in ever-smokers and 56.8ng/mL in nonsmokers. Mean serum ferritin levels were 123.6 in current-smokers and 109.4 in ex-smokers. Serum ferritin levels were higher in smokers and current smokers. According to correlation analysis, ferritin levels demonstrated positive relationship to age and smoking amount(pack-years). On the other hand, serum ferritin concentrations did not correlated with lung function parameters.

CONCLUSIONS: Our data suggest that serum ferritin levels are related with smoking status. It does not show relationship with lung function parameters.

CLINICAL IMPLICATIONS: Further studies are required for investigating role of ferritin in smokers.

DISCLOSURE: The following authors have nothing to disclose: Su Hwan Lee, Eun Young Kim, Sang Kook Lee, Ji Young Hong, Young Sam Kim

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