PURPOSE: Genomic stability is maitained by DNA damage response pathway, and Wip1 plays a important role in DNA damage response through inhibiting several cell cycle protein including p53. Although Wip1 gene amplification was reported in various primary tumors including lung cancer, the biologic significance of its protein expression on patient survival remains unclear in primary lung tumor.We investigated whether Wip1 expression in tumor tissues influenced outcome in these patients.
METHODS: We investigated Wip1 expression by cancer epithelial cells immunohistchemically in 84 consecutive resected cases of lung adenocarcinoma.
RESULTS: Wip1 expression was observed in 54 (64.3%) of the 84 cases. Wip1 expression was found to be significantly correlated with the invasion to pulmonary vein. A univariate analysis and log-rank test demonstrated a significant association between Wip1 expression with lower overall survival rate. A multivariate analysis indicated a statistically significant association between Wip1 expression and lower overall survival rate. Moreover, using subgroup analysis limiting stage I patients, Wip1 expression also significantly related with lower overall survival rate.
CONCLUSIONS: These results indicate that the overexpression of Wip1 in cancer epithelial cells has clinical significance for prognostic evaluation of patients with primary lung adenocarcinoma.
CLINICAL IMPLICATIONS: Overexpression of Wip1 might be a reference index of molecular staging to select patients at high risk of death as well as relapse who may benefit from intensive adjuvant therapy.
DISCLOSURE: The following authors have nothing to disclose: Yoshimasa Maniwa, Wataru Nishio, Masahiro Yoshimura
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