PURPOSE: To describe the clinical characteristics of acute eosinophilic pneumonia (AEP).
METHODS: We reviewed retrospectively consecutive patients who were diagnosed as AEP. The clinical diagnosis of AEP was established by Allen’s criteria. Clinical and radiologic characteristics of patients were collected. Initially the duration of corticosteroid therapy was four weeks. However, the duration was changed to two weeks because of potential side effect of long-term use of steroid.
RESULTS: From May 2007 to October 2010, 82 patients were diagnosed as AEP. Among them, 79 (96.3 %) patients were current smoker and 78 (98.7 %) of patients have a history of starting smoking recently. The duration between starting smoking and visiting of hospital was 20.3 ± 2.04 days. The initial PF ratio was 233.01 ± 6.01. Seventy seven (93.9 %) patients were admitted to intensive care unit (ICU), and mean duration of ICU stay was 2.57 ± 0.15 days. Among 82 patients, only 5 (6.1 %) patients required ventilator care. The percentage of eosinophil in BAL fluid was 42.74 ± 1.51 %, while in blood was 3.70 ± 0.44 %. Radiologic findings were ground glass opacity (96.3 %), air-space consolidation (42.7 %), poorly defined centrilobular nodules (57.3 %), interlobular septal thickening (76.8 %), thickening of bronchovascular bundle (19.5 %), and pleural effusion (92.7 %). Corticosteroid was administrated to all patients. Overall response to corticosteroid therapy was good. There was no case of treatment failure. No case of mortality was occurred. There was no significant differences in the clinical outcome between two and four weeks schedule group.
CONCLUSIONS: Here we described the clinical characteristics of AEP in young male patient. The result of treatment of two weeks schedule was not inferior than four weeks schedule.
CLINICAL IMPLICATIONS: AEP can be treated by two weeks of corticosteroid treatment.
DISCLOSURE: The following authors have nothing to disclose: Chin Rhee, Kyung Min, Kyeongman Jeon
No Product/Research Disclosure Information