0
Poster Presentations: Wednesday, October 26, 2011 |

Transition From Inhaled to Parenteral Treprostinil in Selected Patients With Pulmonary Arterial Hypertension FREE TO VIEW

Ioana Preston, MD; David Ishizawar, MD; Charles Burger, MD; Aaron Waxman, MD; James White, MD; Nicholas Hill, MD
Chest. 2011;140(4_MeetingAbstracts):728A. doi:10.1378/chest.1118203
Text Size: A A A
Published online

Abstract

PURPOSE: Treprostinil is a prostacyclin analog available in inhaled, subcutaneous and intravenous forms. This study investigated the rationale, safety, and tolerability of transition from inhaled to parenteral treprostinil in pulmonary arterial hypertension (PAH).

METHODS: Observational study from 5 PH Centers. Demographics, methods of transition and characteristics before and after transition were recorded. Results are average and standard deviations.

RESULTS: Nine patients (6 females) aged 63±9.8 years were included: idiopathic PAH (2 patients), connective tissue disease-PAH (3 patients), portopulmonary hypertension, chronic thromboembolic-PH, PAH associated with sarcoidosis, and POEMS (1 each). They received inhaled treprostinil for 8±6.6 months before transition, inhaling 58±8 mcg 4 times/day while on phosphodiesterase 5 inhibitors (7 patients) or endothelin receptor antagonists (2 patients). Five had clinical deterioration and 4 inadequate response. In 8 patients right heart catheterization prior to transition showed severe PAH. Transition was carried out in hospital (6 patients), outpatient (2), or home (1). Four patients were transitioned to intravenous and 5 to subcutaneous treprostinil. In 5 patients inhaled treprostinil was down titrated while parenteral drug was uptitrated over several days. In 4 patients, inhaled therapy was stopped and infusion was started at 2-4 ng/kg/min (in 3 patients transition occurred the same day). Patients were followed 5.2±6 months. Treprostinil dose at last follow up was 26±11ng/kg/min. Two patients died after 2.7 and 6.8 months of metastatic carcinoid with pulmonary embolism and pulmonary embolism, respectively and one underwent lung transplantation after 10 months of intravenous therapy. Six patients continue to be on parenteral treprostinil. Functional class improved or was maintained (2.8±0.6 to 2.6±0.5) and brain natriuretic peptide improved in most patients tested at first assessment post-transition. Transition was well tolerated.

CONCLUSIONS: In selected PAH patients who did not respond or deteriorated on inhaled treprostinil, transition to parenteral treprostinil can be done safely in both inpatient and outpatient settings.

CLINICAL IMPLICATIONS: This retrospective study suggests that in selected PAH patients changing one form of prostacyclin delivery to another can be done safely.

DISCLOSURE: Ioana Preston: Grant monies (from industry related sources): Actelion, Bayer, Gilead, Pfizer, United Therapeutics, Consultant fee, speaker bureau, advisory committee, etc.: Actelion, Bayer, Gilead, Pfizer, United Therapeutics

Aaron Waxman: Grant monies (from industry related sources): United Therapeutics

James White: Grant monies (from industry related sources): Actelion, Gilead, United Therapeutics, Consultant fee, speaker bureau, advisory committee, etc.: Gilead, United Therapeutics

Nicholas Hill: Grant monies (from industry related sources): Actelion, Bayer, Gilead, Pfizer, United Therapeutics

The following authors have nothing to disclose: David Ishizawar, Charles Burger

No Product/Research Disclosure Information

09:00 AM - 10:00 AM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543