PURPOSE: COPD should be managed with careful attention paid to comorbidities and their effect on the patient’s quality of life. Depression, one of the systemic comorbidities of COPD, is often underdiagnosed and undertreated. The aim of this study was to assess the prevalence and severity of depression and its influence on quality of life as assessed by COPD Assessment Test (CAT) in COPD patients.
METHODS: A total of 803 patients with COPD were enrolled from 34 tertiary medical centers in South Korea during August and September 2010. All patients were surveyed with the Korean version of CAT and Patient Health Questionnaire-9 (PHQ-9). All patients underwent pulmonary function test as well.
RESULTS: The prevalence of depression was 23.8%. A total 28.7% of patients were not able to do most or everything that that they want to do. The degree of depression, however, was not correlated to the severity of airflow obstruction. When we analyzed the relationship between depression and quality of life, depression itself and its severity exerted heavy impacts on the quality of life in COPD patients (P<0.001). The significant correlations were found between the CAT score and 3 variables (PHQ-9 score, % predicted FEV1 and age) among which PHQ-9 score showed strongest influence.
CONCLUSIONS: The prevalence of depression in COPD patients is considerably high and the depression is exceptionally correlated with the patients' quality of life. In order to enhance the COPD patients' quality of life, the management of depression seems to be prerequisite
CLINICAL IMPLICATIONS: Depression is common and wide spread among COPD patients irrespective of severity of the stage. The quality of life assessed by CAT was significantly affected by the degree of depression measured by PHQ-9.
DISCLOSURE: The following authors have nothing to disclose: Yong Il Hwang, Young Seok Lee, Yeon-Mok Oh, Sang-Do Lee, Sung-Woo Park, Young Sam Kim, Kwang Ho In, Bock Hyun Jung, Kwan Ho Lee, Seung Won Ra, Yong-Bum Park, Ki-Suck Jung
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