PURPOSE: Assessment of preliminary data of respiratory functional test and st. george test in the first 11 patients in our institution.
METHODS: Eleven patients with heterogeneous emphysema in upper lobes observed in high resolution CT Scan, Post-Bronchodilator (PB) FEV1 minor than 45%, Residual Volume (RV) more than 150% and lung difussion DLCO minor than 50%, have been selected to be treated with endobronchial valves type spiration. They have been performed spirometry with bronchodilator test, lung volumes measurement with plethysmography, carbon monoxide difussion test, six minutes walking test and St. George test before and after endobronchial valves placement.
RESULTS: Eleven patients selected (4 women and 7 men) with a mean age of 62.45 years old. Results before treatment: mean PB FEV1 = 927 ml (35.80%), mean PB FVC = 2.372 ml (74%), mean PB FEV1/FVC = 38.80%, mean TLC = 120%, mean RV = 196%, mean DLCO = 47.60%, mean six minutes walking test distance of 419.6 metres. Posterior monitoring has been performed and no significant inprovement has been found in quality of life or functional respiratory test, except in one patient. In 2 patients valves were retired due to clinical worsening.
CONCLUSIONS: Although the preliminary data do not present a significant improvement of functional respiratory test or quality of life with spiration valves, we should perform more studies to look for subgroups of patients with COPD and emphysema that obtain real benefict of this treatment
CLINICAL IMPLICATIONS: This new technique of lung volume reduction with endobronchial valves in patients with COPD and heterogeneous emphysema in upper lobes is reversible and minimally invasive, and could avoid surgery lung volume reduction and its complications.
DISCLOSURE: The following authors have nothing to disclose: Flandes Javier, María Jesús Rodriguez Nieto, Alejandro Martín de San Pablo Sánchez, Iker Fernández Navamuel
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