PURPOSE: Pulmonary hypertension (PH) is a serious disease diagnosed by echocardiography and right heart catheterization. Left ventricular dysfunction and decreased cardiac output is a common feature in pulmonary hypertension. The aim of this study was to evaluate cardiac bioimpedance (CBI) as a possible non-invasive tool in hemodynamic monitoring.
METHODS: 19 patients with IPAH or CTEPH (19-76 years) and 6 healthy volunteers were measured simultaneously by thoracic echocardiography and non-invasive cardiac bioimpedance (CBI) using a BoMed NCCOM3. Parameters were standardized by body surface area. Linear regression analysis and F-Test were performed.
RESULTS: Left ventricular end diastolic volume index in CBI correlated with echocardiography measurements in both M-Mode (r=0,6181; p=0,002) and B-Mode (Simpson, r=0,8431, p<0,001). Also the Stroke index in CBI correlated with the estimated stroke index in M-Mode (r=0,7077; p<0,001) and B-Mode (Simpson, r=0,7946; p<0,001).
CONCLUSIONS: In patients with IPAH or CTEPH, cardiac bioimpedance might be a useful non-invasive tool in monitoring left ventricular hemodynamics including left ventricular preload and cardiac output.
CLINICAL IMPLICATIONS: Cardiac bioimpedance might be useful in evaluation of hemodynamics of patients with pulmonary hypertension during outpatient management once a individual baseline is established. Furthermore it provides additional information on cardiac contractility, which need further investigation in pulmonary hypertension.
DISCLOSURE: The following authors have nothing to disclose: Ralf Kaiser, Christian Lensch, Robert Bals, Heinrike Wilkens
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