PURPOSE: Sarcoidosis is an inflammatory, granulomatous disease of unknown etiology that usually involves the lungs, but may affect any organ in the body. Tenascin-C is an extracellular matrix molecule that may modulate the adhesive and migratory functions of cells and is expressed during inflammation and wound healing in various tissues. Tenascin-C has been reported to be expressed in various respiratory diseases such as sarcoidosis, interstitial pneumonia and cryptogenic organizing pneumonia. The present study was aimed to investigate the role of tenascin-C in the pathogenesis of sarcoidoisis.
METHODS: We used enzyme-linked immunosorbent assays to measure levels of tenascin-C in serum and bronchoalveolar lavage fluid (BALF) from 37 patients with sarcoidosis and 15 healthy individuals.
RESULTS: BALF levels of tenascin-C were significantly elevated in patients with sarcoidosis compared with healthy individuals but not serum levels. The levels of tenascin-C in BALF from patients with sarcoidosis were positively correlated with the percentage of BALF lymphocytes and ratio of CD4+ to CD8+ T-lymphocytes (CD4/CD8 ratio) in BALF. In addition, BALF levels of tenascin-C were higher in the patients with chest X-ray type II and III than those with chest X-ray type 0 and I.
CONCLUSIONS: We conclude that the tenascin-C concentration in BALF is increased in patients with sarcoidosis, especially pulmonary sarcoidosis with chest X-ray type II and III, and positively correlated with the percentage of BAL lymphocytes and CD4/CD8 ratio of T-lymphocytes. These results suggest that tenascin-C in the lung might be involved in the development of granulomas and fibrosis in the lungs of patients with sarcoidosis.
CLINICAL IMPLICATIONS: Tenascin-C concentration in BALF might be one of useful biomarkers for sarcoidosis.
DISCLOSURE: The following authors have nothing to disclose: Yuji Ishimatsu, Hanako Fujita, Noriho Sakamoto, Shota Nakashima, Atsuko Hara, Shintaro Hara, Tomoyuki Kakugawa, Shigeru Kohno
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