Poster Presentations: Wednesday, October 26, 2011 |

Diagnostic Evaluation of Radionuclide Myocardial Imaging and Echocardiography Establishing Myopericardial Involvement in Pulmonary and Systemic Amyloidosis FREE TO VIEW

Ioannis Angomachalelis, PhD; Hercules Titopoulos, PhD; Drosos Tsavlis, PhD; Theodoros Kontakiotis, PhD; Nikolaos Salem, PhD; Demosthenes Bouros, PhD; Nestor Angomachalelis, PhD
Chest. 2011;140(4_MeetingAbstracts):656A. doi:10.1378/chest.1117214
Text Size: A A A
Published online


PURPOSE: Evaluation of radionuclide imaging and echocardiography for clinical diagnostic establishment of myopericardial amyloidosis

METHODS: Ten dyspnea patients(pts),6 males and 4 females,mean age 64 years ,underwent physical examination ,ECG, X-ray and CT, lung function tests and blood gasses, bronchoscopic, pleural and selective multi-organ biopsies, echocardiography and Technetium-99m-pyrophosphate (Tc-99m-pyp) myocardial imaging.Two hours after intravenous injection of 20 mCi, isotope uptake was recorded and classified according to percent bias of precardiac region uptake compared with right parasternal area

RESULTS: 1)Lung function tests of restrictive or conjestive type,cardiomegaly,low ECG voltage,bilateral or unilateral pleural transudates(60%),CT signs of pulmonary systemic disease and pericardial effusion(90/%) 2) Transbronchial and pleural as well as selective cardiac,liver, kidney and rectal biopsies were found compatible with cardiopulmonary and systemic amyloidosis 3)Echocardiographic abnormalities including a) restrictive diastolic dysfunction (100/%) b) ejection fraction<45% (20%), c) asymmetric septal hypertrophy (ASH)=1,5 (90/%) , d) increased ventricular wall (100/%) andinteratrial septal thickness(IAST)(30%) e) interventricular septal granular sparkle appearance (40%) f) pericardial effusion(90%) mainly accompanied by constriction(77%) g) intracavitary thrombi rarely existed 4) abnormal Tc-99m-pyp myocardial imaging(80%)

CONCLUSIONS: ECG low voltage ,pleural transudate,diastolic dysfunction ,ASH with granular sparkle,increased IAST, mainly pericardial constriction and abnormal left parasternal Tc-99m-pyp isotope uptake could be highly suggestive of myo-pericardial amyloidosis

CLINICAL IMPLICATIONS: Further investigation should be carried out,confirming abnormal Tc-99m-pyp imaging and echocardiographic value for the clinical diagnosis of myopericardial amyloidosis,finally replacing organ biopsy

DISCLOSURE: The following authors have nothing to disclose: Ioannis Angomachalelis, Hercules Titopoulos, Drosos Tsavlis, Theodoros Kontakiotis, Nikolaos Salem, Demosthenes Bouros, Nestor Angomachalelis

No Product/Research Disclosure Information

09:00 AM - 10:00 AM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543