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Poster Presentations: Wednesday, October 26, 2011 |

Optimal Technique in Combined Application of Fibrin Glue and Polyglycolic Acid Felt for Alveolar Air Leakage: An Experimental Study FREE TO VIEW

Yasuhiro Tsutani, MD; Keizo Misumi, MD; Takuhiro Ikeda, MD; Yoshihiro Miyata, MD; Yoshitaka Takegawa, PhD; Takanori Uchida, PhD; Morihito Okada, MD
Chest. 2011;140(4_MeetingAbstracts):838A. doi:10.1378/chest.1117181
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Abstract

PURPOSE: We evaluated the sealing effect of fibrin glue and polyglycolic acid (PGA) felt against alveolar air leakage as well as compared various combined application techniques in air leakage models of normal and emphysematous lungs.

METHODS: Rabbit skin with a small defect and a plastic bottle comprised the air leakage model of the normal lung, whereas sponge polyester and a plastic bottle comprised the air leakage model of the emphysematous lung. Defects in both models were covered with fibrin glue and PGA felt using the following three techniques: rubbing fibrinogen solution over the defect, attaching the dry PGA felt to the defect, and spraying fibrinogen and thrombin solutions to the defect (Group I); attaching the felt soaked in fibrinogen solution to the defect and spraying the remaining solutions to the defect (Group II); and attaching and rubbing the felt soaked in fibrinogen solution to the defect and spraying the remaining solutions to the defect (Group III). The minimum seal-breaking pressure was compared among the groups for each model.

RESULTS: In the normal lung model, the seal-breaking pressure was significantly higher in Groups I (mean 362 cmH2O) and III (mean 337 cmH2O) than in Group II (mean 212 cmH2O). In the emphysematous lung model, the seal-breaking pressure was higher in Group III (mean 41 cmH2O) than in Group I (30 cmH2O).

CONCLUSIONS: The technique of attaching and rubbing the felt soaked in fibrinogen solution to the defect and spraying the remaining solutions to the defect was effective against alveolar leakage in both normal and emphysematous lung models.

CLINICAL IMPLICATIONS: The technique of attaching and rubbing the felt soaked in fibrinogen solution to the defect and spraying the remaining solutions to the defect may be effective against alveolar leakage in both normal and emphysematous lungs.

DISCLOSURE: The following authors have nothing to disclose: Yasuhiro Tsutani, Keizo Misumi, Takuhiro Ikeda, Yoshihiro Miyata, Yoshitaka Takegawa, Takanori Uchida, Morihito Okada

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