PURPOSE: Chronic obstructive pulmonary disease (COPD) is recognized as a multi-component disease with impaired health status. Several composite severity indices have been developed and validated for predicting prognosis of patients with COPD. The aim of this study was to evaluate relationships among composite severity indices, depressive and anxious symptoms, and health-related quality of life in patients with COPD.
METHODS: A total of 214 COPD patients from Korean Obstructive Lung Disease (KOLD) cohort who had been followed 1 year after enrollment were analyzed retrospectively. Three composite COPD severity indices; the BODE (body-mass index, airflow obstruction, dyspnea, and exercise capacity), the ADO (age, dyspnea, airflow obstruction) and the DOSE (dyspnea, airflow obstruction, smoking status, and exacerbation frequency) indices were calculated for each COPD patients. Depressive and anxious symptoms were assessed by the validated Korean version of Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Health-related quality of life (HRQOL) was assessed by the validated Korean version of St. George’s Respiratory Questionnaire (SGRQ).
RESULTS: Simple correlation analysis showed a good correlation among three composite severity indices: the BODE and the ADO index (R=0.789, p<0.001), the BODE and the DOSE index (R=0.806, p<0.001), the ADO and the DOSE index (R=0.622, p<0.001). The BDI and the BAI scores showed significant but poor correlations with the BODE, the ADO and the DOSE index (R=0.348, 0.277, 0.375, all p<0.001, respectively, and R=0.257, p<0.001; R=0.16, p=0.02; R=0.31, p<0.001, respectively). SGRQ total scores were well correlated with the BODE, the ADO and the DOSE index (R=0.686, 0.572, 0.689, all p<0.001, respectively), and the BDI and the BAI scores (R=0.630, 0.599, all p<0.001, respectively). Multiple linear regression analysis showed that BDI and BAI scores had independent associations with SGRQ total scores.
CONCLUSIONS: Composite severity indices and depressive and anxious symptoms were independently associated with quality of life in patients with COPD.
CLINICAL IMPLICATIONS: This study indicated that composite COPD severity idices and depressive and anxious symptoms could well predict the health-related quality of life in patients with COPD
DISCLOSURE: Yeon-Mok Oh: Grant monies (from sources other than industry): I have had a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea.
Sang-Do Lee: Grant monies (from sources other than industry): I had a grant of the Korean Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea.
The following authors have nothing to disclose: JaeSeung Lee, Tae-Hyung Kim, Jin Won Huh, KOLD Study Group
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