Slide Presentations: Monday, October 24, 2011 |

Long-term Follow-up in Patients Diagnosed and Treated for Pulmonary Tuberculosis: What Really Happened With the Lung Function? FREE TO VIEW

Pedro Marcos, MD; Isabel Otero, MD; Maria Fernández-Marrube, MD; Maria Rodriguez-Valcarcel, NP; Luis Mariñas, PhD; Laura Nuñez-Naveira, PhD; David Ramos, PhD; Daniel Diaz-Cabanela, MD; Hector Verea, MD
Chest. 2011;140(4_MeetingAbstracts):951A. doi:10.1378/chest.1116907
Text Size: A A A
Published online


PURPOSE: Tuberculosis can affect lung function, but no data exist on long- term follow-up. Tissue remodeling following granulomatous inflammation may underlie functional deterioration after microbiologicalresolution. We performed a long-term evaluation of lung function after diagnosis and treatment of tuberculosis.

METHODS: We studied a cohort of subjects diagnosed with pulmonary tuberculosis and treated in 1996, excluding pleurisy and concomitant disease or HIV infection. The subjects underwent pulmonary function tests, chest x-ray and blood analy- sis for IgE, α-1-antitrypsin and C reactive protein. Pulmonary function data are expressed as percentage of predicted value (mean ± standard deviation).

RESULTS: The cohort comprised 232 cases of which 155 fulfilled inclusion criteria. We recruited 54 subjects that could be located and accepted to participate, aged 44±13; 53.7% were female; 42,6% were smokers averaging 18 pack-years. FEV1 was 88,5% ± 20,6%; 17 subjects (31,5% of study sample) had FEV1 < 80% and 3 subjects (5,5%) had FEV1 < 50%. FVC was 90% ± 13%, and was less than 80% in 10 subjects (18,5%). Four cases (7,4%) had TLC < 80%. The FEV1/FVC ratio was < 70% in 11 cases (20,4%). Two subjects (3,7%) had low α-1-antitrypsin.

CONCLUSIONS: The percentage of smokers was high despite a history of potentially serious lung disease. The prevalence of airflow obstruction is not entirely attributable to tobacco consumption. Despite excluding pleurisy, a restrictive defect was detected in a relevant percentage of subjects. Notwithstanding correct treatment, pulmonary function alterations were found over a decade after the tuberculosis episode.

CLINICAL IMPLICATIONS: Pulmonary TB affects lung function. The prevalence of obstruction and restrictive deffects are high.

DISCLOSURE: The following authors have nothing to disclose: Pedro Marcos, Isabel Otero, Maria Fernández-Marrube, Maria Rodriguez-Valcarcel, Luis Mariñas, Laura Nuñez-Naveira, David Ramos, Daniel Diaz-Cabanela, Hector Verea

No Product/Research Disclosure Information

11:00 AM - 12:30 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543