PURPOSE: To investigate whether common single-nucleotide polymorphisms (SNPs) in -251 and +781 regions of interleukin (IL) -8 gene promoter may be predictive of increased susceptibility to pulmonary tuberculosis (TB).
METHODS: We examined genotype frequencies of the IL-8 promoter polymorphisms - 251A/T and +781C/T on 214 adult patients with pulmonary TB and 202 healthy control subjects with negative tuberculin skin tests from Thai population between June 2007 and July 2010.
RESULTS: Of all 214 cases with pulmonary TB, 154 (72%) and 198 (92.5%) patients were male and new cases of pulmonary TB, respectively. The IL-8 -251TT genotype was associated with increased risk of pulmonary TB, 42.5% versus 30.7% (p = 0.013, OR = 1.67, 95% CI 1.12-2.50) for the control group. Interestingly, an association was found between the IL-8 - 251A/ +781C haplotype and reduced risk of pulmonary TB, 12.1% versus 25.2% (p = 0.001) for the control group. In contrast, no significant association was found between the IL-8 +781C/T either genotypes or alleles and the development of pulmonary TB.
CONCLUSIONS: This study indicates that a common SNP in the IL-8 gene was associated with increased susceptibility to pulmonary TB.
CLINICAL IMPLICATIONS: The SNPs in -251 regions of the IL-8 gene promoter could be predictive of increased susceptibility to pulmonary TB, supporting our hypothesis for IL-8 involvement in pathogenesis of pulmonary TB.
DISCLOSURE: The following authors have nothing to disclose: Anan Wattanathum, Jutharat Saengsawang, Lalita Samran
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