Poster Presentations: Wednesday, October 26, 2011 |

IL-8 (-251)T/A Polymorphism Is Associated With Increased Susceptibility to Pulmonary Tuberculosis in Thailand FREE TO VIEW

Anan Wattanathum, MD; Jutharat Saengsawang, BS; Lalita Samran, BS
Chest. 2011;140(4_MeetingAbstracts):783A. doi:10.1378/chest.1116622
Text Size: A A A
Published online


PURPOSE: To investigate whether common single-nucleotide polymorphisms (SNPs) in -251 and +781 regions of interleukin (IL) -8 gene promoter may be predictive of increased susceptibility to pulmonary tuberculosis (TB).

METHODS: We examined genotype frequencies of the IL-8 promoter polymorphisms - 251A/T and +781C/T on 214 adult patients with pulmonary TB and 202 healthy control subjects with negative tuberculin skin tests from Thai population between June 2007 and July 2010.

RESULTS: Of all 214 cases with pulmonary TB, 154 (72%) and 198 (92.5%) patients were male and new cases of pulmonary TB, respectively. The IL-8 -251TT genotype was associated with increased risk of pulmonary TB, 42.5% versus 30.7% (p = 0.013, OR = 1.67, 95% CI 1.12-2.50) for the control group. Interestingly, an association was found between the IL-8 - 251A/ +781C haplotype and reduced risk of pulmonary TB, 12.1% versus 25.2% (p = 0.001) for the control group. In contrast, no significant association was found between the IL-8 +781C/T either genotypes or alleles and the development of pulmonary TB.

CONCLUSIONS: This study indicates that a common SNP in the IL-8 gene was associated with increased susceptibility to pulmonary TB.

CLINICAL IMPLICATIONS: The SNPs in -251 regions of the IL-8 gene promoter could be predictive of increased susceptibility to pulmonary TB, supporting our hypothesis for IL-8 involvement in pathogenesis of pulmonary TB.

DISCLOSURE: The following authors have nothing to disclose: Anan Wattanathum, Jutharat Saengsawang, Lalita Samran

No Product/Research Disclosure Information

09:00 AM - 10:00 AM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543