0
Poster Presentations: Tuesday, October 25, 2011 |

A Pilot Study to Assess the Efficacy of High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations in Children With Muscle Weakness and Restrictive Lung Disease FREE TO VIEW

Kathryn Fitzgerald, MSN; Jessica Dugre, MSN; Michael Marcus, MD; Sobhan Pagala, BS; Mikhail Kazachkov, MD
Chest. 2011;140(4_MeetingAbstracts):379A. doi:10.1378/chest.1115424
Text Size: A A A
Published online

Abstract

PURPOSE: Children with primary muscle weakness (MW) suffer from insufficient airway secretion clearance (ASC), which predisposes them to lower respiratory tract infections (LRTI) and increases their morbidity. This is a prospective study assessing the efficacy and financial feasibility of aggressive ASC in children with MW and restrictive lung disease (RLD).

METHODS: Aggressive ASC was initiated in twenty-two subjects with MW and RLD related to cerebral palsy, metabolic or genetic syndromes. Twelve months of twice daily HFCWO was used as routine intervention. The first six months of data was excluded from data analysis to allow therapies to become effective, the comparison was made between last six months after enrollment and corresponding six months window before the enrollment. Outcome measures included the cost of hospitalizations, emergency department (ED) visits, antibiotic use, total courses of antibiotics, and the days of hospitalizations before and after intervention.

RESULTS: Implication of aggressive ASC led to a significant reduction in outpatient antibiotic costs ($532 ± $264 and $320 ± $219, P=0.020), a reduction in days of hospitalizations by 46%, hospitalization costs by 42%, and total care costs by 42%. Follow-up data: Analysis of data from fifteen patients that remained in our care for one year after study completion revealed a significant (P=0.046) reduction in total costs compared with the year prior to intervention ($10035 ± $19986 and $1624 ± $4394, P=0.046).

CONCLUSIONS: Aggressive ASC utilizing HFCWO reduced days of hospitalization by 42% in our study population. It showed a significant reduction in outpatient antibiotic costs after one year of intervention, and in total costs in the second year after intervention.

CLINICAL IMPLICATIONS: Aggressive ASC should be strongly recommended in children with MW and RLD.

DISCLOSURE: Kathryn Fitzgerald: Grant monies (from industry related sources): Study was supported by a grant from Hill-Rom, Inc., Consultant fee, speaker bureau, advisory committee, etc.: Received cosultant fees, an on speaker bureau for Hill-Rom, Inc.

Jessica Dugre: Grant monies (from industry related sources): Study was supported by a grant from Hill-Rom

Michael Marcus: Grant monies (from industry related sources): Study was supported by a grant from Hill-Rom

Sobhan Pagala: Grant monies (from industry related sources): Study was supported by a grant from Hill-Rom, Inc.

Mikhail Kazachkov: Grant monies (from industry related sources): Study was supported by a grant from Hill-Rom, Inc.

No Product/Research Disclosure Information

09:00 AM - 10:00 AM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Hypoventilation syndromes. Med Clin North Am 2011;95(6):1189-202.
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543