PURPOSE: Drug-induced lung disease (DILD) is not a rare disease. We should always keep in mind DILD as a differential diagnosis in the medical treatment of the respiratory disease, but the definite diagnosis of the DILD is difficult. In Japan, we often use drug-induced lymphocyte stimulation test (DLST) for the diagnosis of DILD, but there are many uncertainty in the utility and accuracy of DLST. In this study, we investigate the efficacy of DLST and the tendency of DILD in our hospital.
METHODS: 216 patients who carried out DLST in our hospital from 2003 to 2008 were retrospectively investigated.
RESULTS: 216 patients who carried out DLST consisted of 64 patients with liver damage (64), lung diseases (61), eruption (54), fever (16), cytopenia (9), eosinophilia (8), and renal insufficiency (4). In 61 patients who were suspected DILD, 34 patients were diagnosed as DILD based on fulfilling criteria of DILD and their clinical courses. In this study, the sensitivity and the specificity were 67.6% and 81.5%, respectively Poor outcomes were observed in the DILD cases with anticancer drugs and presenting diffuse alveolar damage pattern on chest CT.
CONCLUSIONS: DLST showed relatively low sensitivity and high specificity in the patient suspected DILD.
CLINICAL IMPLICATIONS: It is useful for diagnosing the drug-induced disorders including DILD in the medical treatment of the respiratory disease.
DISCLOSURE: The following authors have nothing to disclose: Hiroshi Ishimoto, Tatsuhiko Harada, Soda Hiroshi, Toshinori Kawanami, Kazuhiro Yatera, Shigeru Kohno, Hiroshi Mukae
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