Poster Presentations: Wednesday, October 26, 2011 |

Clinical Utility of QuantiFERON TB-GOLD in Tube Interferon Gamma Assay in Active Pulmonary Tuberculosis Diagnosis in Korea FREE TO VIEW

Jaeho Chung, MD; Changhoon Han, MD
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Myongji Hospital, Kyunggido, Republic of Korea

Chest. 2011;140(4_MeetingAbstracts):791A. doi:10.1378/chest.1111348
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PURPOSE: New blood based interferon gamma release assays (IGRA) are alternative method for Mycobacterium tuberculosis infection diagnosis. Their role in active pulmonary tuberculosis diagnosis is yet to be defined. The aim of this study was to evaluate the usefulness QuantiFERON TB Gold In-tube assay (QFT-GIT) in the diagnosis of active pulmonary tuberculosis where tuberculosis is endemic and BCG vaccination is mandatory.

METHODS: A total of 72 adult pulmonary tuberculosis patients and 80 controls were included for this study. QFT-GIT method was used to analyze the sensitivity and specificity of IGRA

RESULTS: QFT-GIT and tuberculosis skin test (TST) yielded the diagnostic sensitivities of 88.7% and 62.5%, and specificities of 73.7% and 70.0%, respectively. The combination of the two tests QFT-GIT and TST showed 93.5% sensitivity, however, the specificity was decreased to 44.8%.

CONCLUSIONS: QFT-GIT was highly sensitive in detecting active pulmonary tuberculosis cases. The combination with TST improved the sensitivity of QFT-GIT significantly. Although the higher sensitivity of combination of QFT-GIT and TST may be useful in active TB diagnosis, they are limited by their poor specificity due to the high prevalence of latent TB in our settings

CLINICAL IMPLICATIONS: Clinical Utility of QuantiFERON TB-GOLD in Active pulmonary tuberculosis

DISCLOSURE: The following authors have nothing to disclose: Jaeho Chung, Changhoon Han

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