PURPOSE: The objectives of this study are to obtain the characteristics, variations of the type of mass, diagnostic supporting measures, and mortality factors during hospitalization in 113 patients with mediastinal mass who have been diagnosed and treated in RSCM during a 10-year period.
METHODS: We conducted a descriptive cross-sectional and retrospective case-control study, by browsing through the medical records of 113 mediastinal mass patients who were treated in RSCM, Jakarta, during the period of January 2000- December 2009. This study has been approved by the Ethical Committe of University of Indonesia with the approval number 135/PT02.FK/ETIK2010.
RESULTS: Two hundred and one patients were evaluated and treated. The mean age was 47,1+17.74 years. There were 69 males and 44 females. One-hundred and seven were symptomatic at presentation. Mediastinal tumor was the most common mediastinal mass found among the subjects (44.2%). The most frequent mass location was in the anteriosuperior portion. Chest X-ray imaging were able to detect 61 cases of mediastinal mass. Forty two patients underwent thoracotomy to acquire the histopatologic type of mass. The proportion of mediastinal mass patient mortality during hospitalization reached 39.8%. Sepsis (p = 0,000), superior vena cava syndrome (p = 0,000), and massive pleural effusion (p = 0,047), were found to be statistically significant factors associated with mortality during hospitalization.
CONCLUSIONS: The characteristics and type of mediastinal mass in this study were different with the findings of other studies. The significant and insignificant mortality factors should be noted in the integrated and comprehensive management of mediastinal mass patients.
CLINICAL IMPLICATIONS: Appropriate assessments of these factors is crucial in the management of mediastinal mass, especially as a guideline to determine the diagnostic work-up, choice of medications, and discussion topics with the patients or their relatives to allow the appropriate evaluations in many levels. The increased risk of the patient determines when to carry out aggressive treatment to the patient, in order to provide better outcome in reducing the patient’s suffering and to reduce the mortality rate.
DISCLOSURE: The following authors have nothing to disclose: Gurmeet Singh, Zulkifli Amin, Ign Wuryantoro, Vally Wulani
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