PURPOSE: The purpose of this study was to investigate the risk factors in the development of stroke in an outpatient cardiology practice.
METHODS: Chart reviews were performed in 1675 patients (1189 men and 486 women), mean age 72 ± 12 years. Medication use and co-morbidities were tabulated for each patient. Stepwise Cox regression analyses were used to analyze 42 different variables for statistical significance. The mean follow-up duration was 60 ± 56 months during 1977 to 2008.
RESULTS: Of the 1675 patients, stroke occurred in 97 patients (6%). Stepwise Cox regression analysis showed significant independent risks factors for stroke were statins (hazard ratio = 0.2656, 95% CI, 0.1480 to 0.4766, p <0.0001), carotid stenosis (hazard ratio = 3.7292, 95% CI, 1.7960 to 7.7433, p<0.001), and congestive heart failure (hazard ratio = 2.1369, 95% CI, 1.1046 to 4.1340, p <0.05).
CONCLUSIONS: In an outpatient cardiology practice, use of statins reduced the incidence of stroke. Carotid stenosis and congestive heart failure increased the risk of developing stroke.
CLINICAL IMPLICATIONS: Use of statins significantly reduced the incidence of stroke in an outpatient cardiology practice.
DISCLOSURE: The following authors have nothing to disclose: Hoang Lai, Wilbert Aronow, Anthony Mercando, Mala Sharma, Phoenix Kalen, Harit Desai, Kaushang Gandhi, Harshad Amin, Trung Lai
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