PURPOSE: to elucidate the association of HCV infection with interstitial pulmonary involvement and to investigate the relationship of severity of hepatic affection and respiratory functional and radiological changes among involvement.
METHODS: Thirty patients with proved (HCV) infection from the outpatient clinic of tropical department of Kasr El-Aini hospital were enrolled in this study. Resting spirometry, resting carbon monoxide diffusing capacity (DLCO) & high resolution CT (HRCT) chest, Serology for HCV, abdominal Ultrasound & liver biopsy were performed.
RESULTS: abnormal results of HRCT and DLCO were obtained in 16/30 (53.3%) and 3/23 (13%) patients respectively. Lung spirometry showed obstructive disorder in 3.3% of patients , restrictive disorder in 16.6% of patients, and small airway obstruction in 13.3% of patients. liver fibrosis was assessed by the METAVIR scoring system and there was significant direct correlation between liver fibrosis stages with HRCT score in the studied patients. The study showed significant inverse correlation between viremia level with DLCO% pred as well as significant direct correlation between liver fibrosis stages with AFP, FEV1/FVClevel and HRCT score in the studied patients. In addition AFP was directly correlated with the HRCT score.
CONCLUSIONS: HCV infection is associtated with the development of several pulmonary abnormalities despite the absence of symptoms.
CLINICAL IMPLICATIONS: HRCT is a better diagnostic tool than pulmonary functions in assessment of these pulmonary changes.
DISCLOSURE: The following authors have nothing to disclose: Mohamed Elnady, Nariman Helmy, Hebatullah Assal, Naglaa Abdel Razek, Ahmed Soliman
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