PURPOSE: To assess the safety and efficacy of thoracoscopic doxycycline poudrage (TDP) for pleurodesis in malignant effusions.
METHODS: Twenty seven patients were included in this study. Thoracoscopy was performed for diagnosis and subsequent doxycycline pleurodesis. At the end of thoracoscopy, a new method for Doxycycline delivery to the pleura was used through pneumatic atomizer insufflations where about 500-1000 mg of doxycycline were taken & prepared as a powder from the oral preparation (vibramycin 100 mg / capsule).
RESULTS: 74.1 % had a successful pleurodesis, 18.5% had partial reponse and 7.4% had failed pleurodesis at one month. Adverse effects included pain (48.1%), fever (3.7%) and pain & fever (22.2%). The mean drainage time for intercostals tube was about 1.52 days
CONCLUSIONS: TDP is an inexpensive, well tolerated, reasonably effective, comparatively simple, safe, and capable of alleviating respiratory symptoms.
CLINICAL IMPLICATIONS: TDP in patients with malignant pleural effusions may be a suitable substitute for talc as an effective and well-tolerated pleural sclerosant.
DISCLOSURE: The following authors have nothing to disclose: Mohamed Elnady, Amr Sakr
No Product/Research Disclosure Information