PURPOSE: The best prognosis for lung cancer can be expected by diagnosis at an early stage of the disease. Smoking related tumor more likely arise in the large central airways. but routine check including x-ray and sputum study can not detect early stage tumors. It is known Autofluorescence bronchoscopy can detect them in the large central airways. However we don't use AFB routinely because of invasiveness & evidence deficiency . so we don't know endoscopic abnormal findings of autofluorescence bronchoscopy and pathologic result in heavy smoker.
METHODS: n this study ,239 participants( adults> 50 years old who had smoked at least 30 pack-years ) underwent prevalence screening with autofluorescence bronchoscopy from October 2006 through November 2010.
RESULTS: The mean age of the patients was 61.95±7.1 years. Smoking history were 44.68±14.6 pack.years During the baseline screening , 86 site biopsy was done. Non-specific finding 40(46%),squamous metaplasia 27(31%),fibrous tissue 10(11%), lymphocyte infiltration 6(7%),severe dysplasia 1(1.1%), carcinoma in situ 1(1.1%), invasive squamous cell carcinoma 1(1.1%), and cancer prevalence was 1.25%(3/239) Biopsy site were RUL 22( 25%),RLL 11(13%),LLL 9(10%), Lt.lingular 7(8%),RML 7(8%)trachea 4,carina 5,Rt.main 4, between RUL and bronchus intermedius 5, bronchus intermedius 1,between RML and RLL 3,Lt.main 1, between LUL and LLL 4,between lingular and LUL 3.
CONCLUSIONS: Screening with autofluorescence bronchoscopy in heavy smoker seems to be a promising method for screening lung cancer
CLINICAL IMPLICATIONS: in heavy smoker, If they agree this procedure, It's worth a try.
DISCLOSURE: The following authors have nothing to disclose: Eun Lee
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