Even though we found that thrombocytosis was associated with poor outcomes, Georges and colleagues did not find this association in their population of CAP patients. The authors indicated that our finding of an association between elevated platelet count and poor outcomes “could be explained by the moderate severity of CAP” in the patients in our series, with only 17% of these patients requiring ICU admission. Based on this observation, we may speculate that a low platelet count, being a marker of severe sepsis, predicts poor outcomes in patients with CAP in the ICU. On the other hand, an elevated platelet count may predict poor outcomes in patients with CAP in the absence of severe sepsis. In these patients, platelet-induced thrombus formation may play a role in their clinical outcomes. Using the data they presented, Georges and colleagues stated that in patients with thrombocytosis cause of death was mostly related to complications of ICU stay or comorbidity. It is interesting that in these patients the majority of deaths were likely related to thrombus formation because patients died of cerebrovascular ischemia, mesenteric ischemia, or myocardial infarction. We published an association of acute myocardial infarction and poor outcomes in hospitalized patients with CAP.2 Because platelet-induced thrombus formation may be amenable to treatment, further research is necessary to determine if a causal association exists among CAP, elevated platelet count, thrombus formation, organ ischemia, and clinical outcomes.